Eligibility / Sermorelin

Who can, and can't, start sermorelin.

Sermorelin is a GHRH analog: it asks your pituitary to release growth hormone, rather than supplying HGH directly. The risk profile is different, but the rules around active cancer and severe illness are the same. This page is general information. Whether sermorelin is appropriate for you is decided by an independent, U.S.-licensed provider after your online visit. Compounded medications are not FDA-approved.

✓You may be a fit if

Sermorelin is not a shortcut, and no specific result is promised. It is generally considered for healthy adults. Your provider makes the call.

You are an adult interested in supporting the natural, age-related decline of the GH axis.
You keep up healthy habits (sleep, activity, nutrition). Sermorelin doesn't replace them.
You are comfortable giving yourself a subcutaneous injection on the schedule your provider sets.
You have no active cancer and no serious active illness.

×Contraindications: sermorelin is generally not appropriate

Active or recent malignancy, growth-promoting therapies are inappropriate; oncology clearance required for any history.
Active proliferative diabetic retinopathy.
Critical illness, sepsis, or post-cardiac/abdominal surgery within 12 months.
Significant intracranial hypertension or unexplained severe headaches.
Pituitary tumor, untreated or active.
Pregnancy or breastfeeding.
Hypersensitivity to sermorelin or related peptides.
Severe untreated obstructive sleep apnea.

!Conditions that require extra care

History of cancer in remission, oncology clearance required.
Diabetes / insulin resistance, GH axis activation can affect glucose; your provider may want closer follow-up.
Active joint inflammation, can flare initially.
Carpal tunnel symptoms, can worsen; tell your provider.
Treated obstructive sleep apnea, OK if CPAP-adherent.
IGF-1 known to be at the upper end of normal, tell your provider if you have recent results.

Lab work

Your provider may ask for recent lab results (for example IGF-1 or a metabolic panel) before prescribing or while you are on treatment. What is needed depends on your health history and is decided by your provider.

What to disclose at intake

Any cancer history, including non-melanoma skin cancers.
Any pituitary issue, prior MRI of pituitary, or unexplained vision changes.
Sleep apnea status, diagnosed, treated, or untested.
Diabetes status and current glycemic control.
Any prior peptide use, with substances and dates.
Any HGH use, ever.
Current medications and supplements.

Compounded medication disclaimer

ShyftMD offers compounded sermorelin and compounded semaglutide, prescribed by independent, U.S.-licensed providers through Wasef Health, PC when they decide it is appropriate. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. ShyftMD is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.

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